Publications

Hypertonic lactate to improve cerebral perfusion and glucose availability after acute brain injury

Year: 2018 ISSN:DOI: 10.1097/CCM.0000000000003274

Authors: L. Carteron, D. Solari, C. Patet, H. Quintard, J.-P. Miroz, J. Bloch, R.T. Daniel, L. Hirt, P. Eckert, P.J. Magistretti, M. Oddo

Brain metabolism
Cerebral microdialysis
Cerebral perfusion
Glucose
Hypertonic
Lactate

Impact of MCT1 haploinsufficiency on the mouse retina

Year: 2018 ISSN:DOI: 10.1007/978-3-319-75402-4_46

Authors: N.S. Peachey, M. Yu, J.Y.S. Han, S. Lengacher, P.J. Magistretti, L. Pellerin, N.J. Philp

MCT1
Retina
Lactate
Transgenic mice
Electroretinogram

Lactate in the brain: from metabolic end-product to signalling molecule

Year: 2018 ISSN:DOI: 10.1038/nrn.2018.19

Authors: P.J. Magistretti, I. Allaman

Vasoactive-intestinal-peptide
Glial glutamate transporters
Cerebral cortical astrocytes
Nuclear-magnetic-resonance
Coupling neuronal-activity
Axonal energy-metabolism
Central-nervous-system

Inadequate brain glycogen or sleep increases spreading depression susceptibility

Year: 2017 ISSN:DOI: 10.1002/ana.25122

Authors: K. Kilic, H. Karatas, B. Dönmez‐Demir, E. Eren‐Kocak, Y. Gursoy‐Ozdemir, A. Can, J.-M. Petit, P.J. Magistretti, T. Dalkara

Cerebral cortex
Glutamatergic neurotransmission
Energy metabolism
Astrocytes
Migraine
Depolarizations

Gender-specific alteration of energy balance and circadian locomotor activity in the Crtc1 knockout mouse model of depression

Year: 2017 ISSN:DOI: 10.1038/s41398-017-0023-4

Authors: C. Rossetti, D. Sciarra, J.-M. Petit, C.B. Eap, O. Halfon, P.J. Magistretti, B. Boutrel, J.-R. Cardinaux

Element-binding protein
Creb coactivator crtc2
Body Mass Index
Fat mass
Nuclear receptors
Obesity

Abstractocyte: a visual tool for exploring nanoscale astroglial cells

Year: 2017 ISSN:DOI: 10.1109/TVCG.2017.2744278

Authors: H. Mohammed, A.K. Al-Awami, J. Beyer, C. Cali, P. Magistretti, H. Pfister, M. Hadwiger

Connectomics
Data abstraction
Data visualization
Interactive 3D visualization
Nanoscale devices
Neurons
Neuroscience
Visualization

A preclinical model for identifying rats at risk of alcohol use disorder

Year: 2017 ISSN:DOI: 10.1038/s41598-017-09801-1

Authors: K.S. Jadhav, P.J. Magistretti, O. Halfon, M. Augsburger, B. Boutrel

Addiction-like behavior
Animal-models
Synaptic plasticity
Intermittent access
Drug addiction
Alcohol
Abuse
Neurobiology

Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa

Year: 2017 ISSN:DOI: 10.1038/mp.2017.88

Authors: L.M. Huckins, K. Hatzikotoulas, L. Southam, L.M. Thornton, (...), P.F. Sullivan, G. Breen, C.M. Bulik, E. Zeggini

Anorexia nervosa
Neuropsychiatric disorders
Body weight
GWAS

Gathering by the Red Sea highlights links between environment and epigenetics

Year: 2017 ISSN:DOI: 10.1038/nsmb.3422

Authors: M. Li, E. Borrelli, P.J. Magistretti, J.C.I. Belmonte, P. Sassone-Corsi, V. Orlando

In-vivo
Red Sea
Epigenetics

Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index

Year: 2017 ISSN:DOI: 10.1038/mp.2016.71

Authors: A. Hinney, M. Kesselmeier, S. Jall, A.L. Volckmar, M. Föcker, J. Antel, (...), T.D Müller, J. Hebebrand

Neurotrophic factor gene
Genome-wide association
Food-intake regulation
Dorsal vagal complex
Age-of-onset
Eating-disorders
Bulimia-nervosa
Blood-levels

A historical review of diachrony and semantic dimensions of trace in neurosciences and lacanian psychoanalysis

Year: 2017 ISSN:DOI: 10.3389/fpsyg.2017.00734

Authors: C. Escobar, F. Ansermet, P.J. Magistretti

Diachrony
Engram
Nachträglichkeit (deferred action)
Reassociation
Reconsolidation
Semantics
Syntax
Trace

Role of MCT1 and CAII in skeletal muscle pH homeostasis, energetics, and function: in vivo insights from MCT1 haploinsufficient mice

Year: 2017

Authors: B. Chatel, D. Bendahan, C. Hourdé, L. Pellerin, S. Lengacher, P. Magistretti, Y. Le Fur, Ch. Vilmen, M. Bernard, L.A. Messonnier

Carbonic anhydrases
Magnetic resonance spectroscopy
Monocarboxylate transporters

In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration

Year: 2016

Authors: Suzuki K., Tsunekawa Y., Hernandez-Benitez R., Wu J., (...) Magistretti P., Callaway E.M., Zhang K., Belmonte J.C.

Mammalia
Rattus
Genome
Homology
Engineered nucleases
Biomedical Research

A motion capture study to measure the feeling of synchrony in romantic couples and in professional musicians

Year: 2016 ISSN:DOI: 10.3389/fpsyg.2016.01673

Authors: Preissmann D., Charbonnier C., Chagué S., Antonietti J.P., Llobera J., Ansermet F., Magistretti P.J.

Mirror game
Motion capture
Musicians
Quality of interactions
Subjective feeling
Synchrony

Astrocyte β2-=adrenergic receptors mediate hippocampal long-term memory consolidation

Year: 2016 ISSN:DOI: 10.1073/pnas.1605063113

Authors: Gao V., Suzuki A., Magistretti P.J., Lengacher S., Pollonini G., Steinman M.Q., Alberini C.M.

Astrocyte
Hippocampus
Lactate
Memory
β- Adrenergic receptor

Glutamate cysteine ligase-modulatory subunit knockout mouse shows normal insulin sensitivity but reduced liver glycogen storage

Year: 2016 ISSN:DOI: 10.3389/fphys.2016.00142

Authors: Lavoie S., Steullet P., Kulak A., Preitner F., Do K.Q., Magistretti P.J.

Cortisol
GCLM knockout
Glutathione
Glycemia
Glycogen
Insulin
Resident-intruder stress

Sleep fragmentation alters brain energy metabolism without modifying hippocampal electrophysiological response to novelty exposure

Year: 2016 ISSN:DOI: 10.1111/jsr.12419

Authors: Baud M.O., Parafita J., Nguyen A., Magistretti P.J., Petit J.M.

Strocyte–neurone lactate shuttle
Beta rhythm
Energy metabolism
Exploratory behavior
Neurometabolic coupling

The HDAC inhibitor SAHA improves depressive- like behavior of CRTC1-deficient mice: Possible relevance for treatment-resistant depression

Year: 2016 ISSN:DOI: 10.1016/j.neuropharm.2016.03.012

Authors: Meylan E.M., Halfon O., Magistretti P.J., Cardinaux J.R.

Animal model of depression
Antidepressants
BDNF
CREB coactivator
Epigenetics
HDAC inhibitor
Mood disorders

The subjective sensation of synchrony: an experimental study

Year: 2016 ISSN:DOI: 10.1371/journal.pone.0147008

Authors: Llobera J., Charbonnier C., Chagué S., Preissmann D., Antonietti J.P., Ansermet F., Magistretti P.J.

Synchrony
People behavior
Behavioral mechanisms

In vivo evidence for a lactate gradient from astrocytes to neurons

Year: 2016 ISSN:DOI: 10.1016/j.cmet.2015.10.010

Authors: Mächler P., Wyss M.T., Elsayed M., Stobart J., Gutierrez R., Von Faber-Castell A., Kaelin V., Zuend M., San Martín A., Romero-Gómez I., Baeza-Lehnert F., Lengacher S., Schneider B.L., Aebischer P., Magistretti P.J., Barros L.F., Weber B.

Lactate gradient
Astrocytes
Neurons
Mice
FRET sensor

Three-dimensional immersive virtual reality for studying cellular compartments in 3D models from EM preparations of neural tissues

Year: 2016 ISSN:DOI: 10.1002/cne.23852

Authors: Calì C., Baghabra J., Boges D.J., Holst G.R., Kreshuk A., Hamprecht F.A., Srinivasan M., Lehväslaiho H., Magistretti P.J.

3D analysis
3D navigation
Fast 3D reconstruction
Glycogen clustering
Glycogen spatial distribution

Lactate release from astrocytes to neurons contributes to cocaine memory formation

Year: 2016 ISSN:DOI: 10.1002/bies.201600118

Authors: Boury-Jamot B., Halfon O., Magistretti P.J., Boutrel B.

Astrocyte
Cocaine
Conditioning
Lactate
Memory

A role for lactate in the consolidation of drug-related associative memories

Year: 2016 ISSN:DOI: 10.1016/j.biopsych.2016.04.010

Authors: Boutrel B., Magistretti P.J.

Lactate
Drag-related memories
Drug-paired cues
Long-term memory

Sodium signaling and astrocyte energy metabolism

Year: 2016 ISSN:DOI: 10.1002/glia.22971

Authors: Chatton J.Y., Magistretti P.J., Barros L.F.

Glycolysis
Lactate
Membrane transport
Mitochondria
Na
K-ATPase
Neuron-glia interactions
Syncytium

Imaging brain aerobic glycolysis as a marker of synaptic plasticity

Year: 2016 ISSN:DOI: 10.1073/pnas.1607423113

Authors: Magistretti P.J.

Brain imaging
Positron emission tomography
Functional magnetic resonance imaging

Regulation of neuron-astrocyte metabolic coupling across the sleep-wake cycle

Year: 2016 ISSN:DOI: 10.1016/j.neuroscience.2015.12.007

Authors: Petit J.M., Magistretti P.J.

Adenosine
Gap junctions
Glucose
Glutamate
Lactate
Locus coeruleus

Improvement of neuroenergetics by hypertonic lactate therapy in patients with traumatic brain injury is dependent on baseline cerebral lactate/pyruvate ratio

Year: 2015 ISSN:DOI: 10.1089/neu.2015.4057

Authors: Quintard H., Patet C., Zerlauth J.B., Suys T., Bouzat P., Pellerin L., Meuli R., Magistretti P.J., Oddo M.

Cerebral blood flow
Cerebral microdialysis
Hypertonic
Lactate
Traumatic brain injury

Learning-induced gene expression in thehippocampus reveals a role of neuron – astrocyte metabolic coupling in long term memory

Year: 2015 ISSN:DOI: 10.1371/journal.pone.0141568

Authors: Tadi M., Allaman I., Lengacher S., Grenningloh G., Magistretti P.J.

Avoidance behavior
Brain Mapping
Controlled study
Energy metabolism
Gene
Gene Expression
Glut1 gene

Disrupting astrocyte-neuron lactate transfer persistently reduces conditioned responses to cocaine

Year: 2015 ISSN:DOI: 10.1038/mp.2015.157

Authors: Boury-Jamot B., Carrard A., Martin J.L., Halfon O., Magistretti P.J., Boutrel B.

Astrocyte-neuron lactate
Drug addiction
Glycogen-derived lactate transfer

Influence of MCHR2 and MCHR2-AS1 genetic polymorphisms on body mass index in psychiatric patients and in population-based subjects with present or past atypical depression

Year: 2015 ISSN:DOI: 10.1371/journal.pone.0139155

Authors: Delacrétaz A., Preisig M., Vandenberghe F., Saigi Morgui N., Quteineh L., Choong E., Gholam-Rezaee M., Kutalik Z., Magistretti P., Aubry J.M., Von Gunten A., Castelao E., Vollenweider P., Waeber G., Conus P., Eap C.B.

Atypical depression
Body mass
Controlled study
Gene replication
Genetic association
Haplotype
Heterozygosity

Association of PCK1 with body mass index and other metabolic features in patients with psychotropic treatments

Year: 2015 ISSN:DOI: 10.1097/JCP.0000000000000388

Authors: Saigi Morgui N., Vandenberghe F., Delacrétaz A., Quteineh L., Choong E., Gholamrezaee M., Magistretti P., Aubry J.M., Von Gunten A., Preisig M., Castelao E., Vollenweider P., Waeber G., Kutalik Z., Conus P., Eap C.B.

Body Mass Index
Metabolic syndrome
Pharmacogenetics
Psychotropic drugs

Complex regulation of CREB-binding protein by homeodomain-interacting protein kinase 2

Year: 2015 ISSN:DOI: 10.1016/j.cellsig.2015.08.001

Authors: Kovács K.A., Steinmann M., Halfon O., Magistretti P.J., Cardinaux J.R.

CBP
Coactivator
HIPK2
Protein kinase
Transcriptional regulation

Embodied memory: unconscious smiling modulates emotional evaluation of episodic memories

Year: 2015 ISSN:Doi: 10.3389/fpsyg.2015.00650

Authors: Arminjon M., Preissmann D., Chmetz F., Duraku A., Ansermet F., Magistretti P.J.

Embodied cognition
Facial feedback hypothesis
Memory
Reconsolidation
Somatic markers

Metabolic gene expression changes in astrocytes in Multiple Sclerosis cerebral cortex are indicative of immune-mediated signaling

Year: 2015 ISSN:DOI: 10.1016/j.bbi.2015.04.013

Authors: Eis T., Allaman I., Gentner M., Schroder K., Tschopp J., Magistretti P.J., Schaeren-Wiemers N.

Astrocyte-neuron lactate shuttle
Brain energy homeostasis
Cerebral cortex
Gray matter pathology
Inflammasomes
Multiple Sclerosis
Normal appearing gray matter

Dysregulation of soluble epoxide hydrolase and lipidomic profiles in anorexia nervosa

Year: 2015 ISSN:DOI: 10.1038/mp.2015.26

Authors: Shih P.B., Yang J., Morisseau C., German J.B., Zeeland A.A., Armando A.M., Quehenberger O., Bergen A.W., Magistretti P., Berrettini W., Halmi K.A., Schork N., Hammock B.D., Kaye W.

Adolescent
Adult
Anorexia nervosa
Anxiety
Biological functions
Body mass
Controlled study
Enzyme activity

Neuroenergetic response to prolonged cerebral glucose depletion after severe brain injury and the role of lactate

Year: 2015 ISSN:DOI: 10.1089/neu.2014.3781

Authors: Patet C., Quintard H., Suys T., Bloch J., Daniel R., Pellerin L., Magistretti P., Oddo M.

Brain injury
Cerebral metabolism
Cerebral microdialysis
Glucose
Lactate

Channel-mediated lactate release by K⁺-stimulated astrocytes

Year: 2015 ISSN:DOI: 10.1523/JNEUROSCI.5036-14.2015

Authors: Sotelo-Hitschfeld T., Niemeyer M.I., Mächler P., (....) San Martín A., Le Douce J., Bonvento G., Magistretti P.J., Sepúlveda F.V., Weber B., Barros L.F.

Fluorescence microscopy
Genetically encoded nanosensor
Gliotransmission
Membrane depolarization

Impact of HSD11B1 polymorphisms on BMI and components of the metabolic syndrome in patients receiving psychotropic treatments

Year: 2015 ISSN:DOI: 10.1097/FPC.0000000000000131

Authors: Quteineh L., Vandenberghe F., Saigi Morgui N., Delacrétaz A., Choong E., Gholam-Rezaee M., Magistretti P., Bondolfi G., Von Gunten A., Preisig M., Castelao E., Vollenweider P., Waeber G., Bochud M., Kutalik Z., Conus P., Eap C.B.

Body Mass Index
Metabolic syndrome
Pharmacogenetics
Psychotropic drugs

Multi-timescale modeling of activity-dependent metabolic coupling in the neuron-glia-vasculature ensemble

Year: 2015 ISSN:DOI: 10.1371/journal.pcbi.1004036

Authors: Jolivet R., Coggan J.S., Allaman I., Magistretti P.J.

Computational Biology
Computer Simulation
Extracellular Space
Glucose
Humans
Lactic Acid
Models
Cardiovascular

A new outlook on mental illnesses: glial involvement beyond the glue

Year: 2015 ISSN:DOI: 10.3389/fncel.2015.00468

Authors: Elsayed M., Magistretti P.J.

Astrocyte
Cognition
Glia
Microglia
Mood
NG2 glia
Oligodendrocyte
Psychiatric disorder

A cellular perspective on brain energy metabolism and imaging

Year: 2015 ISSN:DOI: 10.1016/j.neuron.2015.03.035

Authors: Magistretti P.J., Allaman I.

Animals
Astrocytes
Brain
Energy metabolism
Glucose
Humans
Magnetic Resonance Imaging
Neurons

Alzheimer's disease: the amyloid hypothesis and the Inverse Warburg effect

Year: 2015 ISSN:DOI: 10.3389/fphys.2014.00522

Authors: Demetrius L.A., Magistretti P.J., Pellerin L.

Age-related disease
Inverse cancer comorbidity
Metabolic alteration
Mitochondrial dysregulation
The inverse warburg effect

Astrocytes: new targets for the treatment of neurodegenerative diseases

Year: 2015 ISSN:DOI: 10.2174/1381612821666150710144502

Authors: Finsterwald C., Magistretti P.J., Lengacher S.

Alzheimer disease
Amyotrophic Lateral Sclerosis
Astrocyte
Glia
Lactate
Metabolism
Neurodegeneration
Parkinson's disease

Goals in nutrition science 2015-2020

Year: 2015 ISSN:Doi: 10.3389/fnut.2015.00026

Authors: Allison D.B., Bassaganya-Riera J., Burlingame B., Brown A.W., Le Coutre J., Dickson S.L., Van Eden W., Garssen J., Hontecillas R., Khoo C.S., Knorr D., Kussmann M., Magistretti P.J., Mehta T., Meule A., Rychlik M., Vögele C.

Nutrition
Food
Mitigating Errors
Big Data Analysis

Deficiency in monocarboxylate transporter 1 (MCT1) in mice delays regeneration of peripheral nerves following sciatic nerve crush

Year: 2015 ISSN:DOI: 10.1016/j.expneurol.2014.10.018

Authors: Morrison B.M., Tsingalia A., Vidensky S., Lee Y., Jin L., Farah M.H., Lengacher S., Magistretti P.J., Pellerin L., Rothstein J.D.

Axon
Dorsal root ganglion
Electron microscopy
Metabolism
Monocarboxylate transporter
Nerve crush
Perineurial cell
Peripheral nerve
Regeneration
Schwann cell

High throughput second harmonic imaging for label-free biological applications

Year: 2014 ISSN:DOI: 10.1364/OE.22.031102

Authors: Macias-Romero C., Didier M.E., Jourdain P., Marquet P., Magistretti P., Tarun O.B., Zubkovs V., Radenovic A., Roke S.

Electrochemical response
Interfacial process
Mammalian neurons
Near infrared femtosecond laser

Sustained sleep fragmentation induces sleep homeostasis in mice

Year: 2014 ISSN:DOI: 10.5665/sleep.4572

Authors: Baud M.O., Magistretti P.J., Petit J.M.

BDNF
Heat shock proteins
Paradoxical sleep
Sleep apneas
Sleep fragmentation
Slow waves
Spindles
SWA

Hypertonic lactate and the injured brain: facts and the potential for positive clinical implications

Year: 2014 ISSN:DOI: 10.1007/s00134-014-3312-x

Authors: Bouzat P., Magistretti P.J., Oddo M.

Brain Injuries
Humans
Hypertonic Solutions
Lactic Acid

Control of mitochondrial pH by uncoupling protein 4 in astrocytes promotes neuronal survival

Year: 2014 ISSN:DOI: 10.1074/jbc.M114.570879

Authors: Perreten Lambert H., Zenger M., Azarias G., Chatton J.Y., Magistretti P.J., Lengacher S.

Adenosine triphosphate
Animals
Astrocytes
Carbon Dioxide
Cell Survival
Coculture Techniques

Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons

Year: 2014 ISSN:DOI: 10.1073/pnas.1322912111

Authors: Yang J., Ruchti E., Petit J.M., Jourdain P., Grenningloh G., Allaman I., Magistretti P.J.

Astrocyte-neuron interaction
Astrocyte-neuron lactate shuttle
Brain energy metabolism
Learning and memory

Increased activation in Broca's area after cognitive remediation in schizophrenia

Year: 2014 ISSN:DOI: 10.1016/j.pscychresns.2014.01.004

Authors: Vianin P., Urben S., Magistretti P., Marquet P., Fornari E., Jaugey L.

Executive function
Frontal area
Functional magnetic resonance imaging
Verbal fluency
Verbalization

Cerebral metabolic effects of exogenous lactate supplementation on the injured human brain

Year: 2014 ISSN:DOI: 10.1007/s00134-013-3203-6

Authors: Bouzat P., Sala N., Suys T., Zerlauth J.B., Marques-Vidal P., Feihl F., Bloch J., Messerer M., Levivier M., Meuli R., Magistretti P.J., Oddo M.

Brain metabolism
Cerebral microdialysis
Hypertonic
Lactate
Traumatic brain injury

Review of quantitative phase-digital holographic microscopy: promising novel imaging technique to resolve neuronal network activity and identify cellular biomarkers of psychiatric disorders

Year: 2014 ISSN:DOI: 10.1117/1.NPh.1.2.020901

Authors: Marquet P., Depeursinge C., Magistretti P.J.

Cell count
Cell motion
Cell structure
Cell volume
Holography
Human
Mental disease
Microscopy

Glycogen metabolism and the homeostatic regulation of sleep

Year: 2014 ISSN:DOI: 10.1007/s11011-014-9629-x

Authors: Petit J.M., Burlet-Godinot S., Magistretti P.J., Allaman I.

Brain
Energy metabolism
Glia
Glucocorticoïds
Noradrenaline
PTG

Synaptic plasticity and the Warburg effect

Year: 2014 ISSN:DOI: 10.1016/j.cmet.2013.12.012

Authors: Magistretti P.J.

Brain
Gene Expression Regulation
Developmental
Glycolysis
Humans

Resistance to diet-induced obesity and associated metabolic perturbations in haploinsufficient monocarboxylate transporter 1 mice

Year: 2013 ISSN:DOI: 10.1371/journal.pone.0082505

Authors: Lengacher S., Nehiri-Sitayeb T., Steiner N., Carneiro L., Favrod C., Preitner F., Thorens B., Stehle J.C., Dix L., Pralong F., Magistretti P.J., Pellerin L.

Animals
beta-Galactosidase
Body Composition
Diet
High-Fat
Eating
Female
Male
Mice
Knockout

The human CFTR protein expressed in CHO cells activates aquaporin-3 in a cAMP-dependent pathway: study by digital holographic microscopy

Year: 2013 ISSN:DOI: 10.1242/jcs.133629

Authors: Jourdain P., Becq F., Lengacher S., Boinot C., Magistretti P.J., Marquet P.

Aquaporin AQP3
CAMP pathway
CFTR protein
Digital holographic microscopy
F508del-CFTR
Water transport

Genes involved in the astrocyte-neuron lactate shuttle (ANLS) are specifically regulated in cortical astrocytes following sleep deprivation in mice

Year: 2013 ISSN:DOI: 10.5665/sleep.3034

Authors: Petit J.M., Gyger J., Burlet-Godinot S., Fiumelli H., Martin J.L., Magistretti P.J.

Energy metabolism
Fow cytometry
Glia
Glucose
Glutamate
Transgenic mice

Evidence for the role of EPHX2 gene variants in anorexia nervosa

Year: 2013 ISSN:DOI: 10.1038/mp.2013.91

Authors: Scott-Van Zeeland A.A., Bloss C.S., Tewhey R., Bansal V., Torkamani A., Libiger O., Duvvuri V., Wineinger N., Galvez L., Darst B.F., Smith E.N., Carson A., Pham P., Phillips T., (...) Magistretti P., Bergen A.W., Berrettini W., Kaye W., Schork N.J.

Anorexia nervosa
EPHX2
Genomics
Hyperlipidemia
Pooling
Sequencing

Cerebral extracellular lactate increase is predominantly nonischemic in patients with severe traumatic brain injury

Year: 2013 ISSN:DOI: 10.1038/jcbfm.2013.142

Authors: Sala N., Suys T., Zerlauth J.B., Bouzat P., Messerer M., Bloch J., Levivier M., Magistretti P.J., Meuli R., Oddo M.

Cerebral blood flow
Cerebral metabolism
Cerebral microdialysis
Lactate
Traumatic brain injury

Influence of CRTC1 polymorphisms on body mass index and fat mass in psychiatric patients and the general adult population

Year: 2013 ISSN:DOI: 10.1001/jamapsychiatry.2013.187

Authors: Choong E., Quteineh L., Cardinaux J.R., Gholam-Rezaee M., Vandenberghe F., Dobrinas M., Bondolfi G., Etter M., Holzer L., Magistretti P., Others

Adiposity
Adult
Body Mass Index
Case-Control Studies
Genetic Predisposition to Disease
Humans
Male
Mental Disorders

Astrocyte-neuron co-culture on microchips based on the model of SOD mutation to mimic ALS

Year: 2013 ISSN:DOI: 10.1039/c3ib40022k

Authors: Kunze A., Lengacher S., Dirren E., Aebischer P., Magistretti P.J., Renaud P.

Amyotrophic Lateral Sclerosis
Animals
Astrocytes
Cell Communication
Coculture Techniques
Mice
Microfluidics
Microscopy
Confocal
Motor Neurons

The psychostimulant modafinil enhances gap junctional communication in cortical astrocytes

Year: 2013 ISSN:DOI: 10.1016/j.neuropharm.2013.04.019

Authors: Liu X., Petit J.M., Ezan P., Gyger J., Magistretti P., Giaume C.

Astrocytes
Connexins
Gap junctions
Glia
Modafinil
Sleep

Measurement of absolute cell volume, osmotic membrane water permeability, and refractive index of transmembrane water and solute flux by digital holographic microscopy

Year: 2013 ISSN:DOI: 10.1117/1.JBO.18.3.036007

Authors: Boss D., Kühn J., Jourdain P., Depeursinge C., Magistretti P.J., Marquet P.

Absolute cell volume
Digital holographic microscopy
Dry mass concentration
Intracellular refractive index
Osmotic membrane water permeability
Transmembrane solute transport

Peripuberty stress leads to abnormal aggression, altered amygdala and orbitofrontal reactivity and increased prefrontal MAOA gene expression

Year: 2013 ISSN:DOI: 10.1038/tp.2012.144

Authors: Márquez C., Poirier G.L., Cordero M.I., Larsen M.H., Groner A., Marquis J., Magistretti P.J., Trono D., Sandi C.

Analysis of Variance
Animals
Clorgyline
Conditioning (Psychology)
Disease Models
Animal
Fear
Gene Expression
Immunohistochemistry

Exploring neural cell dynamics with digital holographic microscopy

Year: 2013 ISSN:DOI: 10.1146/annurev-bioeng-071812-152356

Authors: Marquet P., Depeursinge C., Magistretti P.J.

Cell imaging
Dendritic spines
Diffraction tomography
Digital holographic microscopy
Neuronal activities

The challenge of connecting the dots in the B.R.A.I.N.

Year: 2013 ISSN:DOI: 10.1016/j.neuron.2013.09.008

Authors: Devor A., Bandettini P.A., Boas D.A., Bower J.M., Buxton R.B., Cohen L.B., (...) Jernigan T.L., Judd L.L., Kim S.G., Kleinfeld D., Kopell N.J., Kutas M., Kwong K.K., Larkum M.E., Lo E.H., Magistretti P.J., Others

Animals
Biomedical Research
Brain Mapping
Humans
Neurosciences

Regulation of neurotrophic factors and energy metabolism by antidepressants in astrocytes

Year: 2013 ISSN:DOI: 10.2174/1389450111314110009

Authors: Martin J.L., Magistretti P.J., Allaman I.

Antidepressants
Astrocyte-neuron cooperation
Astrocytes
BDNF
Glucose metabolism
Lactate
Neurotrophic factors

Simultaneous optical recording in multiple cells by digital holographic microscopy of chloride current associated to activation of the ligand-gated chloride channel GABA(A) receptor

Year: 2012 ISSN:DOI: 10.1371/journal.pone.0051041

Authors: Jourdain P., Boss D., Rappaz B., Moratal C., Hernandez M.C., Depeursinge C., Magistretti P.J., Marquet P.

Chloride Channels
Chlorides
Gamma-Aminobutyric Acid
HEK293 Cells
Holography
Humans
Ion Channel Gating
Membrane Potentials
Microscopy
Receptors

New evidence of neuroprotection by lactate after transient focal cerebral ischaemia: extended benefit after intracerebroventricular injection and efficacy of intravenous administration

Year: 2012 ISSN:DOI: 10.1159/000343657

Authors: Berthet C., Castillo X., Magistretti P.J., Hirt L..

Cerebral ischaemia
Lactate
Middle cerebral artery occlusion
Neuroprotection
Stroke
Translational research

Label-free cytotoxicity screening assay by digital holographic microscopy

Year: 2012 ISSN:DOI: 10.1089/adt.2012.476

Authors: Kühn J., Shaffer E., Mena J., Breton B., Parent J., Rappaz B., Chambon M., Emery Y., Magistretti P., Depeursinge C., Marquet P., Turcatti G.

Biological Assay
Drug Evaluation
Preclinical
Equipment Design
Equipment Failure Analysis
Holography
Image Interpretation

Spatially-resolved eigenmode decomposition of red blood cells membrane fluctuations questions the role of ATP in flickering

Year: 2012 ISSN:DOI: 10.1371/journal.pone.0040667

Authors: Boss D., Hoffmann A., Rappaz B., Depeursinge C., Magistretti P.J., Van De Ville D., Marquet P.

Adenosine triphosphate
Algorithms
Erythrocyte deformability
Erythrocyte membrane
Erythrocytes
Humans

Sustained sleep fragmentation affects brain temperature, food intake and glucose tolerance in mice

Year: 2012 ISSN:DOI: 10.1111/j.1365-2869.2012.01029.x

Authors: Baud M.O., Magistretti P.J., Petit J.M.

Glucocorticoids
Locomotor activity
Metabolism
Obstructive sleep apnea

Oligodendroglia metabolically support axons and contribute to neurodegeneration

Year: 2012 ISSN:DOI: 10.1038/nature11314

Authors: Morrison B.M., Lee Y., Li Y., Lengacher S., Farah M.H., Liu Y., Tsingalia A., Jin L., Zhang P.W., Griffin J.W., Pellerin L., Magistretti P.J., Rothstein J.D.

Biochemistry
Brain
Cytology
Epidemiology
Functional role
Glucose
Metabolite
Nervous system disorder
Neurology
Rodent
Survival
Tumor

Deletion of CREB-regulated transcription coactivator 1 induces pathological aggression, depression-related behaviors, and neuroplasticity genes dysregulation in mice

Year: 2012 ISSN:DOI: 10.1016/j.biopsych.2012.04.011

Authors: Breuillaud L., Rossetti C., Meylan E.M., Mérinat C., Halfon O., Magistretti P.J., Cardinaux J.R.

Antidepressant
BDNF
CREB
Fluoxetine
Major depression
Mood disorders
Neuroplasticity genes regulation
Transcriptional coactivator

Brain lactate metabolism in humans with subarachnoid haemorrhage

Year: 2012 ISSN:DOI: 10.1161/STROKEAHA.111.648568

Authors: Oddo M., Levine J.M., Frangos S., Maloney-Wilensky E., Carrera E., Daniel R.T., Levivier M., Magistretti P.J., LeRoux P.D.

Brain hypoxia
Cerebral metabolism
Hyperglycolysis
Lactate
Subarachnoid hemorrhage

Early cell death detection with digital holographic microscopy

Year: 2012 ISSN:DOI: 10.1371/journal.pone.0030912

Authors: Pavillon N., Kühn J., Moratal C., Jourdain P., Depeursinge C., Magistretti P.J., Marquet P.

Brain cell
Cell death
Cell viability
Cell volume
Controlled study
Digital holographic microscopy
Early diagnosis
Microscopy
Mouse
Nonhuman
Quantitative analysis
Signal detection

Sweet sixteen for ANLS

Year: 2012 ISSN:DOI: 10.1038/jcbfm.2011.149

Authors: Pellerin L., Magistretti P.J.

Astrocytes
Brain imaging
Energy metabolism
Lactate
Neurodegeneration
Neuronal-glial interaction

Memory reconsolidation: trace reassociation and the freudian unconscious

Year: 2012 ISSN:DOI: 10.1016/B978-0-12-386892-3.00014-7

Authors: Alberini C.M., Ansermet F., Magistretti P.

Consolidation
Freud
Memory
Psychoanalyss
Reconsolidation
Retrieval
Unconscious

Publications

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