Professor Pierre Magistretti

Principal Investigator

Dean, BESE Division
Distinguished Professor, Bioscience

Current

Research Interests

​Cellular and molecular bases of brain energy metabolism 

Behavioral, cellular and molecular determinants of neuronal and glial plasticity 

Energy metabolism in neuropsychiatric disorders 

Cellular and molecular bases of functional brain imaging 

Functions of glia 

Regulation of gene expression in the brain 

Neurotransmitters in the brain : Localization, Release, Cellular actions 

Dialogue between neuroscience and psychoanalysis

Selected Publications

  • Role of MCT1 and CAII in skeletal muscle pH homeostasis, energetics, and function: in vivo insights from MCT1 haploinsufficient mice
    B. Chatel, D. Bendahan, C. Hourdé, L. Pellerin, S. Lengacher, P. Magistretti, Y. Le Fur, Ch. Vilmen, M. Bernard, L.A. Messonnier
    The FASEB Journal, fj. 201601259R, 2017
  • A historical review of diachrony and semantic dimensions of trace in neurosciences and lacanian psychoanalysis
    C. Escobar, F. Ansermet, P.J. Magistretti
    Frontiers in Psychology 8, 734, 2017
  • Protein targeting to glycogen is a master regulator of glycogen synthesis in astrocytes
    E. Ruchti, P.J. Roach, A.A. DePaoli-Roach, P.J. Magistretti, I. Allaman
    IBRO Reports 1, 46-53, 2016
  • Comparisons of verbal fluency brain correlates between adults and adolescents suffering from schizophrenia spectrum disorders: A pilot study
    S. Urben, L. Jaugey, E. Fornari, P. Magistretti, P. Marquet, L. Holzer, P. Vianin
    The European Journal of Psychiatry 30 (4), 249-257, 2016
  • In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration
    K. Suzuki, Y. Tsunekawa, R. Hernandez-Benitez, J. Wu, J. Zhu, E.J. Kim, (...), P. Magistretti, K. Zhang, E.M. Callaway, K. Zhang, J.C.I. Belmonte
    Nature 540 (7631), 144-149, 2016
  • Lactate release from astrocytes to neurons contributes to cocaine memory formation
    B. Boury‐Jamot, O. Halfon, P.J. Magistretti, B. Boutrel
    BioEssays 38 (12), 1266-1273, 2016
  • Adding large EM stack support
    G. Holst, S. Berg, K. Kare, P. Magistretti, C. Cali
    Information Technology (Big Data Analysis)(KACSTIT), Saudi International Conference, 2016
  • Peripheral administration of lactate produces antidepressant-like effects
    A. Carrard, M. Elsayed, M. Margineanu, B. Boury-Jamot, L. Fragnière, E.M. Meylan, J-M. Petit, H. Fiumelli, P.J. Magistretti, J-L Martin
    Molecular psychiatry, 2016
  • A key role of astrocytic lactate in the formation and maintenance of memories associated with cocaine-associated cues
    B.B. Jamot, A. Carrard, J. Martin, O. Halfon, P. Magistretti, B. Boutrel
    European Neuropsychopharmacology 26, S138, 2016

Education

  • ​Ph.D., Biology, University of California, San Diego, 1982 
  • M.D., University of Geneva, 1979 
  • Diplôme Fédéral de Médecin, University of Geneva, 1977

Professional Profile

  • ​2012 – Current: Distinguished Professor and Dean, Division of Biological and Environmental Sciences and Engineering, KAUST, Thuwal, Saudi Arabia 
  • 2005: Professor, Brain Mind Institute, Swiss Federal Institute of Technology (EPFL) 
  • 2004 – 2012: Professor, Center for Psychiatric Neuroscience, Department of Psychiatry University of Lausanne Medical School and Hospitals (UNIL-CHUV) 
  • 2008 – 2012: Director, Brain Mind Institute, Federal Institute of Technology (EPFL), Lausanne (Joint appointment with UNIL-CHUV) 
  • 2005 – 2008: Co-Director, Brain Mind Institute, Federal Institute of Technology (EPFL), Lausanne (Joint appointment with UNIL-CHUV) 
  • 2001 – 2003: Chairman, Department of Physiology, University of Lausanne Medical School (Co-Chairman in 2004) 
  • 1996 – 2000: Vice-Dean for Preclinical Departments, University of Lausanne Medical School 
  • 1988 – 2004: Professor of Physiology, University of Lausanne Medical School

Scientific and Professional Membership

  • ​Federation of European Neuroscience Societies (FENS) (President 2002 – 2004) 
  •  International Society of Cerebral Blood Flow and Metabolism (Board of Directors, 1999 - 2003) 
  •  Société de Neuroendocrinologie Expérimentale (Member of the Council, 1994 - 1997) 
  •  Société des Neurosciences, France (Member of the Council, 1993 - 2000) 
  •  Société Suisse de Psychiatrie Biologique (Member of the Council, 1992 - 1995) 
  •  Société Suisse de Pharmacologie et de Toxicologie 
  •  European Neuroscience Association 
  •  Society for Neuroscience (USA) 
  •  Société Suisse de Physiologie

Awards

  • ​2015 Co-recipient with Drs David Attwell (UCL) and Markus Raichle (Washington University) of the 2016 IPSEN Foundation Prize (Topic for 2016: Neuroenergetics) 
  • 2014 Honorary member of the Chinese Association for Physiological Sciences 
  • 2011 Elected Member of the American College of NeuroPsychopharmacology (ACNP) 
  • 2011 Camillo Golgi Medal Award, Golgi Fondation 
  • 2009 Goethe Award for Psychoanalytic Scholarship, Canadian Psychological Association 
  • 2007 International Chair Professor, Collège de France, Paris, 2007-2008 
  • 2002 Recipient of the Emil Kraepelin Guest Professorship, Max Planck Institute für Psychiatry, Münich 
  • 2001 Elected Member of the Swiss Academy of Medical Sciences, ad personam 
  • 2001 Elected Member of Academia Europaea 
  • 1997 Recipient of the Theodore-Ott Prize of the Swiss Academy of Medical Sciences

KAUST Affiliations

​Biological and Environmental 
Science & Engineering Division (BESE)

Research Interests Keywords

Brain energy metabolism Neuropsychiatric disorders Functional brain imaging Gene expression