Fouad Lemtiri-Chlieh, PhD

Research Interests

Lactate, produced by astrocytes, is shuttled into neurons to sustain the high energetic demand of neurons. Dr. Fouad is looking at how Lactate helps neuroprotection. To answer some aspects of this question, he is using Patch-Clamp Electrophysiology and calcium imaging techniques on two experimental models (i) cultured cell lines heterologously expressing NMDAR subunits (NR1::NR2A or NR2B) and (ii) brain slice preparations.

Selected Publications

A guide to transient expression of membrane proteins in HEK-293 cells for functional characterization
A. Ooi, A. Wong, L. Essau, F. Lemtiri-Chlieh, C.A. Gehring
Frontiers in Physiology, 7(300) 1-15, (2016)
Functional characterisation of an intron retaining K+ transporter of barley reveals intron‐mediated alternate splicing
K. Shahzad, M. Rauf, M. Ahmed, Z.A. Malik, I. Habib, Z. Ahmed, K. Mahmood, R. Ali, K. Masmoudi, F. Lemtiri‐Chlieh, C.A. Gehring, G.A. Berkowitz, N.A. Saeed
Plant Biology, 17(4) 840-851, (2015)
Characterization of heterologously expressed transporter genes by patch- and voltage-clamp methods: application to cyclic nucleotide-dependent responses
F. Lemtiri‐Chlieh, R. Ali
Methods in Molecular Biology, Humana Press, 1016, pp. 67-93, (2013)
Cyclic nucleotides and nucleotide cyclases in plant stress responses in Abiotic Stress Response in Plants
F .Lemtiri-Chlieh, L. Thomas, C. Marondedze, H. Irving, C. Gehring
Physiological, Biochemical and Genetic Perspectives, Arun K. Shanker and B. Venkateswarlu (Ed.), ISBN: 978-953-307-672-0, InTech, DOI: 10.5772/24757, (2011)
Kalirin-7 is necessary for normal NMDA receptor-dependent synaptic plasticity
F. Lemtiri-Chlieh, L. Zhao, D.D. Kiraly, B.A. Eipper, R.E. Mains, E.S. Levine
BMC Neuroscience 12, 126, (2011)
Kalirin binds the NR2B subunit of the NMDA receptor, altering its synaptic localization and function
D.D. Kiraly, F. Lemtiri-Chlieh, E.S. Levine, R.E. Mains, B.A. Eipper
Journal of Neuroscience, 31, 12554-12565, (2011)
Induced pluripotent stem cell models of the genomic imprinting disorders Angelman and Prader-Willi syndromes
S.J. Chamberlain, P-F. Chen, K.Y. Ng, KY, F. Bourgeois-Rocha, F. Lemtiri-Chlieh, E.S. Levine, M. Lalande
Proceedings of the National Academy of Sciences of the United States of America, 107, 17668-17673, (2010)
BDNF evokes release of endogenous cannabinoids at layer 2/3 inhibitory synapses in the neocortex
F. Lemtiri-Chlieh, E.S. Levine
Journal of neurophysiology, 104(4), 1923-1932, (2010)
Lack of depolarization-induced suppression of inhibition (DSI) in layer 2/3 interneurons that receive cannabinoid-sensitive inhibitory inputs
F. Lemtiri-Chlieh, E.S. Levine
Journal of neurophysiology, 98(5), 2517-2524, (2007)
Death don't have no mercy and neither does calcium: Arabidopsis CYCLIC NUCLEOTIDE GATED CHANNEL2 and innate immunity
R. Ali, W. Ma, F. Lemtiri-Chlieh, D. Tsaltas, Q. Leng, S. Von Bodman, G. A. Berkowitz
The Plant Cell, 19(3), 1081-1095, (2007)

Education

Ph.D., Cellular Biology, Université Claude Bernard Lyon I, France (UCBL), 1990
M.Sc., Differentiation, Genetics and Immunology, UCBL, Lyon, France, 1986
B.Sc., Physiology (Neurosciences major), UCBL, Lyon, France, 1985

Professional Profile

2010 – Current: Research Scientist, KAUST, Thuwal, Saudi Arabia
2001 – 2010: Postdoctral Fellow and Visiting Assistant professor, UConn, CT, USA
1991 – 2001: Postdoctoral Fellow, Cambridge University, Cambridge, UK

Scientific and Professional Membership

Society for Neuroscience (Sfn)
American Society of Plant Biologists (ASPB)
Editorial Board Member of Frontiers

Awards

Biotechnology and Biological Sciences Research Council (BBSRC), UK, 1999
Targets and functions of inositol hexakisphophate action in plants (fund award reference: P11978)

KAUST Affiliations

Biological and Environmental  Science & Engineering Division (BESE)

Research Interests Keywords

Neurotoxicity Lactate neuroprotection NMDARs Electrophysiology